Precision-Guided Therapy™ for the Human Upgrade Era
528 Innovations is at the forefront of laser technology development for biohacking. Laser technology has made significant strides in becoming accessible for personal health optimization. 528 Innovations has truly reengineered laser therapy with 528i Laser Therapy Systems, giving solutions to enhance health and performance by modulating light to achieve precise biological effects.
What if light could help rewire the brain, accelerate recovery, and unlock new levels of human performance?
In this episode of The Human Upgrade, Dave Asprey sits down with Dr. Brandon Crawford, functional neurologist and founder of 528 Innovations, to explore the cutting edge of Precision-Guided Laser Therapy™ for the brain and body.
Dr. Crawford explains how targeted wavelengths, pulsed frequencies, and photobiomodulation may influence brainwaves, vagus nerve function, mitochondrial signaling, mood, gut-brain communication, and nervous system resilience.
Click to watch: This conversation dives into the future of biohacking — where light, frequency, neuroplasticity, and recovery science converge to support cognition, performance, emotional regulation, and whole-body optimization.
Guided Experiences. Engineered for Repeatable Results
Which Wavelength Approach Is Right for You?
The Science Behind the Wavelength
975nm near-infrared light interacts with the body differently than many traditional photobiomodulation wavelengths. Unlike wavelengths primarily associated with deeper mitochondrial stimulation.
This wavelength range is specifically of interest in discussions surrounding Exclusion Zone (EZ) water — the structured, gel-like phase of water believed to play a role in cellular hydration, energy transfer, and biological function. Because water strongly absorbs energy in the 975nm range, this wavelength may help support fluid dynamics, vascular response, and tissue hydration pathways that contribute to comfort, circulation, and recovery-focused applications.
Commonly used for:
Pain and comfort-focused applications
Soft tissue recovery support
Circulation and vascular support
Tissue warming and localized blood flow
Fluid movement and edema support
Hydration and water-interaction focused applications
Superficial-to-mid depth soft tissue applications
Recovery and tissue comfort protocols
The Science Behind the Wavelength
808nm is considered a “deep-reaching metabolic wavelength.” Because it has relatively low water absorption, more light energy can travel deeper into tissue before being absorbed. Photobiomodulation using 808nm wavelength has been studied for decades across rehabilitation, sports medicine, neurology, and wellness applications.
Commonly used for:
Muscles, joints, nerves, and deeper tissues
Performance recovery and muscle fatigue
Cellular repair, recovery, communication and function - Mitochondrial support and ATP production
Circulation and tissue oxygenation
Joint & tissue repair and recovery support
Mobility & flexibility
Deep tissue applications
Peripheral nerve support
The Science behind the Wavelength
( Coming Soon! )
528nm Green Light — Regulatory & Sensory Signaling Support
528nm is considered a “surface-level regulatory wavelength.” Unlike deeper-penetrating infrared wavelengths, green light interacts more strongly with superficial vascular tissues, sensory signaling pathways, and surface chromophores involved in biological communication and tissue regulation. Photobiomodulation using green wavelengths in the 520–532nm range is increasingly being explored for non-thermal musculoskeletal comfort and sensory modulation applications.
405nm Violet Light — Surface Photochemical & Biological Response Support
405nm is considered a “high-energy surface interaction wavelength.” Because violet light is absorbed strongly near the skin surface, it is primarily associated with photochemical interaction, skin-environment modulation, and localized biological signaling. Photobiomodulation using 405nm wavelengths has been studied in dermatological, microbial, and surface-level tissue applications where shallow penetration and targeted surface interaction are desired.
The nervous system, mitochondria, circulation, recovery capacity, sleep quality, and cellular resilience all influence how effectively the body responds to stress, training, and optimization strategies.
Access an expanding library of expert-designed therapy experiences through the 528i Mobile App. With new categories, collections, and collaborative content planned from leaders in health, wellness, and performance, your 528i system is designed to evolve long after purchase.
The 528i ecosystem was engineered with clinical intent and precision, combining:
Multi-step sequencing
Targeted placement visuals
Preset timing guidance
Wavelength-specific protocols
Goal-based recovery and performance programs
While both LEDs and lasers contribute to photobiomodulation, lasers remain the preferred technology when deeper penetration, precision dosing, and targeted therapeutic delivery matter most.
The result is a structured system that removes guesswork and helps users integrate laser therapy into a larger performance and recovery stack with clarity and confidence.
TECHSTACK
Lymphatic System Support
Stimulate lymphatic drainage, circulation, and inflammation control. Targeted light supports tissue detox and immune response before or after compression therapy, accelerating recovery and improving fluid movement at the cellular level. The 528i Mobile App provides a search field to support your interest.
Physical Restoration
Total Body Recovery - a Targeted laser therapy preset exclusive to the 528i Mobile App™ enhances neuromuscular readiness and recovery when paired with a vibration plate. Accelerate post-training recovery and support cellular hydration (EZ water), mobility, and muscle recovery while relieving pain from strain, injury, or dysfunction, restoring whole-body function through optimized tissue repair & energy flow.
Cellular Energy & Optimization
Red and near-infrared light activate mitochondrial respiration, improve circulation, and support lymphatic flow. 528i Mobile App’s Precision-Guided Therapy ™ library is designed to promote ATP production, electrical coherence, and systemic regulation, making them an ideal complement to support recovery, detoxification, and bioelectrical resilience.
LIGHTHACK
Relaxation & Stress Managment
Target vagal tone and parasympathetic activation using key brainstem and nerve frequencies - helping reduce stress and promote calm. The Rest & Repair Category, exclusive to the 528i Mobile App, educates your post EGG experience to amplify cellular response.
Lower Systemic Inflammation
The Inflammation and LimbFlow Illuminate presets complement the biological goals of Cryotherapy by supporting reduced systemic inflammation, improved circulation, metabolism, and immune function. Paired with cold exposure, targeted red and near-infrared light help accelerate cellular repair, calm pro-inflammatory signaling, and enhance circulation for improved tissue oxygenation, detoxification, and recovery. The 528i Mobile App recover more effectively after cryotherapy or periods of chronic inflammation.
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